Aug 25, 2023
This episode of Brain Science features
the return of molecular biologist Seth Grant. We briefly review his decades of
research into the complexity of the protein structure of the
synapse and then we focus on his most recent paper, which describes
how the life-span of synapse proteins appears to change as animals
age. Grant reflects of the significance of this finding both for
animal research and human medicine.
Papers discussed in this
- Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D.
G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A.,
Merino-Serrais, P., Husi, E., Mendive-Tapia, L., Vendrell, M.,
O'Dell, T. J., DeFelipe, J., Komiyama, N. H., Holtmaat, A.,
Fransén, E., & Grant, S. G. N. (2022). A brain atlas of synapse
protein lifetime across the mouse lifespan. Neuron, 110(24),
- Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama, N.
H., Fransén, E., & Grant, S. G. N. (2020). A brainwide atlas of
synapses across the mouse life span. Science (New York, N.Y.),
369(6501), 270–275. https://doi.org/10.1126/science.aba3163
Seth Grant has previously appeared on Brain
Science several times including BSP 51, BSP 101, BS 137, BSP 150 and BS 176.
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